SCHEMBL5224422

SCHEMBL5224422

CCCCc1oc2cc(C(=O)O)ccc2c1C(=O)c1ccc(OCCCBr)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 1/20 0.61
KDM5A P29375 1/20 0.58
KDM7A Q6ZMT4 1/20 0.58
SIRT3 Q9NTG7 7/20 0.55
ESR1 P03372 1/20 0.53
PGR P06401 1/20 0.53
CHRM2 P08172 1/20 0.53
HTR1A P08908 1/20 0.53
ADRA2A P08913 1/20 0.53
ADORA3 P0DMS8 1/20 0.53
CHRM1 P11229 1/20 0.53
DRD1 P21728 1/20 0.53
TBXA2R P21731 1/20 0.53
SLC6A2 P23975 1/20 0.53
PDE4A P27815 1/20 0.53
SLC6A4 P31645 1/20 0.53
ADRA1A P35348 1/20 0.53
OPRM1 P35372 1/20 0.53
DRD3 P35462 1/20 0.53
SLC6A3 Q01959 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5221622 0.92 NR1H4 (0.61) NR1H4KDM5AKDM7AESR1PGR
SCHEMBL5671830 0.90 KDM5A (0.56) KDM5AKDM7ASIRT3ESR1PGR
SCHEMBL5228679 0.88 NR1H4 (0.61) NR1H4KDM5AKDM7AESR1PGR
SCHEMBL10857421 0.86 KDM5A (0.76) NR1H4KDM5AKDM7ASIRT3
SCHEMBL3251537 0.86 NR1H4 (0.56) NR1H4KDM5AKDM7ASIRT3
SCHEMBL2040079 0.83 ESR1 (0.59) KDM5AKDM7AESR1PGRCHRM2
SCHEMBL10672374 0.82 KDM5A (0.76) NR1H4KDM5AKDM7ASIRT3
SCHEMBL5225986 0.82 ESR1 (0.73) ESR1PGRCHRM2HTR1AADRA2A
SCHEMBL5674727 0.82 ESR1 (0.60) ESR1PGRCHRM2HTR1AADRA2A
SCHEMBL5223415 0.81 ESR1 (0.57) ESR1PGRCHRM2HTR1AADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1315710-B1 AMINOALKOXYBENZOYL-BENZOFURAN OR BENZOTHIOPHENE DERIVATIVES, METHOD FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME SANOFI AVENTIS (FR) 2007-04-25 EP disclosed
EP-1315710-A1 AMINOALKOXYBENZOYL-BENZOFURAN OR BENZOTHIOPHENE DERIVATIVES, METHOD FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME SANOFI-SYNTHELABO (FR) 2003-06-04 EP disclosed
WO-2002016340-A1 AMINOALKOXYBENZOYL-BENZOFURAN OR BENZOTHIOPHENE DERIVATIVES, METHOD FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME SANOFI-SYNTHELABO (FR) 2002-02-28 WO disclosed