Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 16/20 | 0.54 |
| ▸ | ESR1 | P03372 | 14/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378367 | 0.85 | ESR2 (0.67) | ESR2ESR1 | |
| SCHEMBL3402023 | 0.81 | ESR2 (0.72) | ESR2ESR1 | |
| SCHEMBL3924579 | 0.77 | ESR2 (0.48) | ESR2ESR1 | |
| SCHEMBL22310241 | 0.72 | ESR2 (0.51) | ESR2ESR1 | |
| SCHEMBL1378632 | 0.70 | ESR2 (1.00) | ESR2ESR1 | |
| Prinaberel SCHEMBL1379424 | 0.70 | ESR2 (1.00) | ESR2ESR1 | |
| SCHEMBL3930286 | 0.70 | ESR2 (0.43) | ESR2ESR1 | |
| SCHEMBL3398729 | 0.69 | DHODH (0.56) | ESR2ESR1DHODH | |
| Prinaberel SCHEMBL3613805 | 0.69 | ESR2 (0.98) | ESR2ESR1 | |
| SCHEMBL121323 | 0.69 | DHODH (0.70) | ESR2DHODHMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781628-A2 | PRODRUG SUBSTITUTED BENZOXAZOLES AS ESTROGENIC AGENTS | Wyeth a Corporation of the State of Delaware (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006026316-A2 | PRODRUG SUBSTITUTED BENZOXAZOLES AS ESTROGENIC AGENTS | WYETH (US) | 2006-03-09 | — | — | WO | disclosed |