Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 1/20 | 0.49 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28173370 | 0.73 | HRH3 (0.57) | PLD1KDM4E | |
| SCHEMBL28101766 | 0.72 | HRH3 (0.56) | PLD1 | |
| SCHEMBL15800694 | 0.71 | PLD1 (0.73) | PLD1MEN1USP2ALDH1A1CYP3A4 | |
| SCHEMBL21353591 | 0.71 | — | — | |
| SCHEMBL29857922 | 0.71 | PLD1 (0.73) | PLD1MEN1USP2ALDH1A1CYP3A4 | |
| SCHEMBL6499166 | 0.71 | PLD1 (0.44) | PLD1MEN1USP2ALDH1A1CYP3A4 | |
| SCHEMBL243658 | 0.71 | PLD1 (0.58) | PLD1GPR119MEN1USP2ALDH1A1 | |
| SCHEMBL1245662 | 0.71 | PLD1 (0.58) | PLD1CHI3L1GPR119ALDH1A1SMN1; SMN2 | |
| SCHEMBL29683564 | 0.71 | PLD1 (0.58) | PLD1GPR119MEN1USP2ALDH1A1 | |
| SCHEMBL359401 | 0.71 | PLD1 (0.58) | PLD1GPR119MEN1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841768-A1 | PURINE DERIVATIVES ACTING AS A2A RECEPTOR AGONISTS | Novartis AG (CH) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006074925-A1 | PURINE DERIVATIVES ACTING AS A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2006-07-20 | — | — | WO | disclosed |