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SCHEMBL5224527

SCHEMBL5224527

CC(=O)ON1C(=O)[C@@H](N(C(=O)Cc2cc(F)cc(F)c2)C(=O)[C@H](C)N)[C@@H](c2ccccc2)Oc2ccccc21

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ PSEN1 P49768 5/20 0.32
▸ PSEN2 P49810 5/20 0.32
▸ APH1B Q8WW43 5/20 0.32
▸ NCSTN Q92542 5/20 0.32
▸ APH1A Q96BI3 5/20 0.32
▸ PSENEN Q9NZ42 5/20 0.32
▸ GSAP A4D1B5 1/20 0.32
▸ MEN1 O00255 1/20 0.31
▸ KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3342704 0.88 PSEN1 (0.39) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL3342670 0.87 XIAP (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5227404 0.87 XIAP (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL3341068 0.85 MME (0.38) MEN1KMT2A
SCHEMBL3343473 0.84 MEN1 (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL3343364 0.84 MEN1 (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL3349431 0.83 MEN1 (0.34) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL3344935 0.83 F10 (0.37) PSEN1PSEN2APH1BNCSTNAPH1A
Hydrochloric Acid SCHEMBL3555507 0.83 F10 (0.36) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL5225483 0.82 F10 (0.42) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1845089-A1 Novel lactams and uses thereof AstraZeneca AB (SE) 2007-10-17 — — EP disclosed