Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.33 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3342670 | 1.00 | XIAP (0.35) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3342704 | 0.91 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3341068 | 0.90 | MME (0.38) | KMT2AMEN1F2F10PRSS1 | |
| SCHEMBL3343364 | 0.87 | MEN1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5224527 | 0.87 | PSEN1 (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3343473 | 0.87 | MEN1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3344935 | 0.86 | F10 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3349431 | 0.86 | MEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL3555507 | 0.85 | F10 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5225483 | 0.83 | F10 (0.42) | KMT2AMEN1F2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845089-A1 | Novel lactams and uses thereof | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |