SCHEMBL5224648

SCHEMBL5224648

CC(C)(C)[C@H](O)CN

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL140067 1.00
SCHEMBL8846452 1.00
Hydrochloric Acid SCHEMBL30939140 0.97
Hydrochloric Acid SCHEMBL22287292 0.97
Ammonia Solution, Strong SCHEMBL7663383 0.97
Hydrochloric Acid SCHEMBL2520308 0.97
Formic Acid SCHEMBL4623888 0.87 TSHR (0.42)
SCHEMBL10363139 0.83 TSHR (0.39)
SCHEMBL26618612 0.81
SCHEMBL3309787 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250282725-A1 KCNQ POTENTIATORS Eii Lilly and Company 2025-09-11 US disclosed
US-12344584-B2 KCNQ potentiators ELI LILLY AND COMPANY (US) 2025-07-01 US disclosed
US-20240076269-A1 KCNQ POTENTIATORS Eii Lilly and Company (US) 2024-03-07 US disclosed
US-11840516-B2 KCNQ potentiators ELI LILLY AND COMPANY (US) 2023-12-12 US disclosed
US-11840516-B2 KCNQ potentiators ELI LILLY AND COMPANY (US) 2023-12-12 US disclosed
US-11840516-B2 KCNQ potentiators ELI LILLY AND COMPANY (US) 2023-12-12 US disclosed
EP-3921030-B1 1-((2-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-4-YL)METHYL)UREA DERIVATIVES AS KCNQ POTENTIATORS LILLY CO ELI (US) 2023-10-11 EP disclosed
EP-3921030-B1 1-((2-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-4-YL)METHYL)UREA DERIVATIVES AS KCNQ POTENTIATORS LILLY CO ELI (US) 2023-10-11 EP disclosed
US-20220073464-A1 KCNQ POTENTIATORS ELI LILLY AND COMPANY 2022-03-10 US disclosed
US-20220073464-A1 KCNQ POTENTIATORS ELI LILLY AND COMPANY 2022-03-10 US disclosed
CN-113692304-A 1- ((2- (2,2, 2-trifluoroethoxy) pyridin-4-yl) methyl) urea derivatives as KCNQ enhancers 礼来公司 2021-11-23 CN disclosed
WO-2020163268-A1 1-((2-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-4-YL)METHYL)UREA DERIVATIVES AS KCNQ POTENTIATORS ELI LILLY AND COMPANY (US) 2020-08-13 WO disclosed
WO-2020163268-A1 1-((2-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-4-YL)METHYL)UREA DERIVATIVES AS KCNQ POTENTIATORS ELI LILLY AND COMPANY (US) 2020-08-13 WO disclosed
US-20200247752-A1 KCNQ Potentiators ELI LILLY AND COMPANY (US) 2020-08-06 US disclosed
US-20200247752-A1 KCNQ Potentiators ELI LILLY AND COMPANY (US) 2020-08-06 US disclosed
EP-0910564-B1 D-AMINO ACID DERIVED INHIBITORS OF CYSTEINE AND SERINE PROTEASES CEPHALON INC (US) 2007-10-31 EP disclosed
EP-0910564-A4 1999-04-28 EP disclosed
EP-0910564-A1 D-AMINO ACID DERIVED INHIBITORS OF CYSTEINE AND SERINE PROTEASES CEPHALON, INC. (US) 1999-04-28 EP disclosed
US-5852007-A Cysteine and serine protease inhibitors containing D-amino acid at the P2 position, methods of making same, and methods of using same CEPHALON, INC. (US) 1998-12-22 US disclosed
WO-1997021690-A1 D-AMINO ACID DERIVED INHIBITORS OF CYSTEINE AND SERINE PROTEASES CEPHALON, INC. (US) 1997-06-19 WO disclosed