Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.54 |
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 8/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5098517 | 0.92 | ALDH1A1 (0.62) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL9515788 | 0.91 | MAPT (0.63) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL5092055 | 0.85 | ALDH1A1 (0.59) | ALDH1A1MAPTL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL5483633 | 0.81 | MAPT (0.65) | ALDH1A1MAPTL3MBTL1CYP2C19LMNA | |
| SCHEMBL22471070 | 0.80 | ALDH1A1 (0.61) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL22471148 | 0.80 | MAPT (0.62) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL22470988 | 0.79 | MAPT (0.50) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL22471135 | 0.79 | MAPT (0.60) | ALDH1A1MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL2062011 | 0.79 | MAPT (0.63) | ALDH1A1MAPTL3MBTL1CYP2C19LMNA | |
| SCHEMBL22471055 | 0.79 | KDM4E (0.51) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812425-A2 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006047479-A2 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |