Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.76 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640302 | 0.89 | HDAC1 (0.89) | KCNH2HDAC1HDAC2HDAC3 | |
| SCHEMBL8161162 | 0.89 | HDAC1 (0.70) | KCNH2HDAC1HDAC2HDAC3 | |
| SCHEMBL6205553 | 0.88 | HDAC1 (0.64) | KCNH2HDAC1HDAC2HDAC3 | |
| SCHEMBL20181480 | 0.86 | KCNH2 (1.00) | KCNH2HDAC1HDAC2HDAC3 | |
| SCHEMBL5224545 | 0.86 | HDAC1 (0.70) | KCNH2HDAC1HDAC2HDAC3 | |
| SCHEMBL1639098 | 0.86 | HDAC1 (0.87) | KCNH2HDAC1HDAC2HDAC3 | |
| SCHEMBL1640715 | 0.86 | HDAC1 (0.77) | KCNH2HDAC1HDAC2HDAC3 | |
| SCHEMBL5226783 | 0.86 | HDAC1 (0.59) | KCNH2HDAC1HDAC2HDAC3 | |
| SCHEMBL1640917 | 0.85 | HDAC1 (0.82) | KCNH2HDAC1HDAC2HDAC3 | |
| SCHEMBL1640681 | 0.85 | HDAC1 (1.00) | KCNH2HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501508-B1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | EP | disclosed |
| US-20050222410-A1 | Inhibitors of histone deacetylase | ASTRAZENECA AB (SE) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222410-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | KCNH2 2503/4885HDAC1 1/4885HDAC2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.