Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225414 | 0.94 | KCNH2 (0.57) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL5225255 | 0.88 | KCNH2 (0.76) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL22738120 | 0.83 | HDAC2 (0.71) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL20181677 | 0.81 | HDAC2 (0.69) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL12193402 | 0.80 | HDAC1 (0.59) | HDAC1HDAC2HDAC3 | |
| SCHEMBL1639152 | 0.79 | HDAC1 (0.68) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL1640302 | 0.79 | HDAC1 (0.89) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL5224627 | 0.79 | HDAC1 (0.56) | HDAC1HDAC2HDAC3 | |
| SCHEMBL8161162 | 0.79 | HDAC1 (0.70) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL1640845 | 0.79 | HDAC1 (0.67) | HDAC1KCNH2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501508-A1 | INHIBITORS OF HISTONE DEACETYLASE | Astrazeneca AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003092686-A1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2003-11-13 | — | — | WO | disclosed |