Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1S | Q13698 | 6/20 | 0.55 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.49 |
| ▸ | ITGAL | P20701 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | SCN1A | P35498 | 2/20 | 0.48 |
| ▸ | SCN4A | P35499 | 2/20 | 0.48 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225757 | 0.78 | ITGB2 (0.50) | CACNA1SITGB2ICAM1ITGALCYP3A4 | |
| SCHEMBL7330715 | 0.78 | CACNA1S (0.80) | CACNA1SITGB2ICAM1ITGALCYP3A4 | |
| SCHEMBL7326317 | 0.78 | CACNA1S (0.80) | CACNA1SITGB2ICAM1ITGALCYP3A4 | |
| SCHEMBL7330718 | 0.78 | CACNA1S (0.80) | CACNA1SITGB2ICAM1ITGALCYP3A4 | |
| SCHEMBL7326309 | 0.78 | CACNA1S (0.80) | CACNA1SITGB2ICAM1ITGALCYP3A4 | |
| Hydrochloric Acid SCHEMBL9505100 | 0.76 | ITGB2 (0.50) | CACNA1SITGB2ICAM1ITGALCYP3A4 | |
| SCHEMBL10538420 | 0.76 | CACNA1S (0.60) | CACNA1SITGB2ICAM1ITGALCYP3A4 | |
| SCHEMBL9505980 | 0.76 | CACNA1S (0.60) | CACNA1SITGB2ICAM1ITGALCYP3A4 | |
| SCHEMBL9506823 | 0.75 | CACNA1S (0.62) | CACNA1SITGB2ICAM1ITGALCYP3A4 | |
| SCHEMBL24711104 | 0.74 | CACNA1S (0.66) | CACNA1SCYP3A4LMNAABCB11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845089-A1 | Novel lactams and uses thereof | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |
| EP-1554250-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004031154-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |