Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.50 |
| ▸ | ITGAL | P20701 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 3/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.43 |
| ▸ | HRH2 | P25021 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343427 | 0.82 | GSK3B (0.43) | TP53MAPTSMN1; SMN2RAB9ASLC6A3 | |
| SCHEMBL11435169 | 0.80 | CACNA1S (0.65) | KDM1ACACNA1SCACNA1CLMNACYP3A4 | |
| SCHEMBL5225360 | 0.78 | CACNA1S (0.55) | ITGB2ICAM1ITGALKDM1ACACNA1S | |
| SCHEMBL10809571 | 0.71 | ITGB2 (0.53) | ITGB2ICAM1ITGALKDM1ACACNA1S | |
| SCHEMBL3346744 | 0.69 | OPRK1 (0.40) | ITGB2ICAM1ITGALKDM1ACACNA1S | |
| Hydrochloric Acid SCHEMBL9505100 | 0.69 | ITGB2 (0.50) | ITGB2ICAM1ITGALKDM1ACACNA1S | |
| Thiazesim SCHEMBL30263577 | 0.69 | GSK3B (0.65) | KDM1ACACNA1STP53MAPTSMN1; SMN2 | |
| Thiazesim SCHEMBL49862 | 0.69 | GSK3B (0.65) | KDM1ACACNA1STP53MAPTSMN1; SMN2 | |
| SCHEMBL10808149 | 0.68 | ITGB2 (0.55) | ITGB2ICAM1ITGALKDM1ACACNA1S | |
| SCHEMBL10538420 | 0.68 | CACNA1S (0.60) | ITGB2ICAM1ITGALKDM1ACACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845089-A1 | Novel lactams and uses thereof | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |