Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 8/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.48 |
| ▸ | SNCA | P37840 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224309 | 0.85 | MET (0.47) | HDAC2KCNH2HDAC3HDAC1HDAC4 | |
| SCHEMBL5226704 | 0.83 | HDAC2 (0.76) | HDAC2KCNH2HDAC3HDAC1HDAC4 | |
| SCHEMBL6203588 | 0.82 | HDAC2 (0.43) | HDAC2HDAC3HDAC1HDAC4HDAC7 | |
| Acetic Acid SCHEMBL6206022 | 0.80 | HDAC2 (0.69) | HDAC2KCNH2HDAC3HDAC1HDAC4 | |
| Acetic Acid SCHEMBL6206020 | 0.79 | HDAC2 (0.74) | HDAC2KCNH2HDAC3HDAC1HDAC4 | |
| SCHEMBL4161740 | 0.75 | HDAC2 (0.74) | HDAC2KCNH2HDAC3HDAC1HDAC4 | |
| SCHEMBL20181525 | 0.75 | HDAC2 (1.00) | HDAC2KCNH2HDAC3HDAC1HDAC4 | |
| SCHEMBL4733917 | 0.73 | HDAC2 (0.56) | HDAC2KCNH2HDAC3HDAC1HDAC4 | |
| SCHEMBL27620288 | 0.71 | HDAC2 (0.63) | HDAC2KCNH2HDAC3HDAC1HDAC4 | |
| SCHEMBL20181507 | 0.71 | KCNH2 (1.00) | HDAC2KCNH2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501508-B1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | EP | disclosed |
| US-20050222410-A1 | Inhibitors of histone deacetylase | ASTRAZENECA AB (SE) | 2005-10-06 | — | — | US | disclosed |
| EP-1501508-A1 | INHIBITORS OF HISTONE DEACETYLASE | Astrazeneca AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003092686-A1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222410-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | HDAC2 4/4885KCNH2 2503/4885HTT 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.