Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.57 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.57 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.57 |
| ▸ | KIT | P10721 | 3/20 | 0.57 |
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | FLT1 | P17948 | 3/20 | 0.57 |
| ▸ | FLT4 | P35916 | 3/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.57 |
| ▸ | STK16 | O75716 | 2/20 | 0.57 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.57 |
| ▸ | TAOK2 | Q9UL54 | 2/20 | 0.57 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227042 | 0.92 | KDR (0.69) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL5228442 | 0.88 | KDR (0.59) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5225853 | 0.84 | KDR (0.56) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5225570 | 0.82 | KDR (0.41) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14419332 | 0.81 | KDR (0.77) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL5226467 | 0.81 | KDR (0.60) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5225821 | 0.81 | KDR (0.57) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4981197 | 0.80 | KDR (0.69) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL5226899 | 0.80 | KDR (0.72) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4977022 | 0.80 | KDR (0.64) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | claimed |