Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 1.00 |
| ▸ | DPP7 | Q9UHL4 | 16/20 | 1.00 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5237003 | 0.99 | DPP4 (0.98) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL5229043 | 0.92 | DPP4 (1.00) | DPP4DPP7DPP9DPP8CYP2D6 | |
| SCHEMBL21068050 | 0.85 | DPP4 (1.00) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL5230578 | 0.85 | DPP4 (1.00) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL21068052 | 0.85 | DPP4 (1.00) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL5227446 | 0.84 | DPP4 (1.00) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL5229936 | 0.83 | DPP4 (0.71) | DPP4DPP7DPP9DPP8CYP2D6 | |
| SCHEMBL5227962 | 0.83 | DPP4 (0.80) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL5232810 | 0.81 | DPP4 (0.84) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL5227098 | 0.80 | DPP4 (0.75) | DPP4DPP7DPP9DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390809-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for diabetes | MERCK & CO., INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-7390809-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for diabetes | MERCK & CO., INC. (US) | 2008-06-24 | — | — | US | disclosed |
| EP-1554280-B1 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO INC (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1554280-B1 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO INC (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2004032836-A2 | ANTIDIABETIC BETA-AMINO HETEROCYLCIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO., INC. (US) | 2004-04-22 | — | — | WO | disclosed |