Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 5/20 | 0.34 |
| ▸ | BCHE | P06276 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225992 | 1.00 | OPRM1 (0.35) | OPRM1OPRD1OPRK1RIPK1ABCB1 | |
| SCHEMBL5224893 | 0.96 | OPRM1 (0.34) | OPRM1OPRD1OPRK1RIPK1ABCB1 | |
| SCHEMBL5224898 | 0.96 | OPRM1 (0.34) | OPRM1OPRD1OPRK1RIPK1ABCB1 | |
| SCHEMBL5220640 | 0.95 | MME (0.35) | OPRM1OPRD1OPRK1RIPK1ABCB1 | |
| SCHEMBL5220642 | 0.95 | MME (0.35) | OPRM1OPRD1OPRK1RIPK1ABCB1 | |
| SCHEMBL5220125 | 0.89 | PSEN1 (0.35) | OPRM1OPRD1OPRK1ABCB1BACE1 | |
| SCHEMBL5220129 | 0.89 | PSEN1 (0.35) | OPRM1OPRD1OPRK1ABCB1BACE1 | |
| SCHEMBL5223629 | 0.87 | PSEN1 (0.36) | OPRM1OPRD1OPRK1ABCB1TRPA1 | |
| SCHEMBL5223634 | 0.87 | PSEN1 (0.36) | OPRM1OPRD1OPRK1ABCB1TRPA1 | |
| SCHEMBL5217827 | 0.86 | PSEN1 (0.35) | OPRM1OPRD1OPRK1ABCB1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |