Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5088823 | 0.87 | FOLH1 (0.46) | SMN1; SMN2MAPK1TAS1R3TAS1R1ATM | |
| SCHEMBL4685821 | 0.83 | ATM (0.63) | SMN1; SMN2MAPK1TAS1R3TAS1R1ATM | |
| SCHEMBL3812659 | 0.81 | ATM (0.62) | MAPK1TAS1R3TAS1R1ATMNPC1 | |
| SCHEMBL1553456 | 0.79 | FOLH1 (0.51) | SMN1; SMN2MAPK1ATMFOLH1L3MBTL1 | |
| SCHEMBL1461981 | 0.79 | ATM (0.60) | SMN1; SMN2MAPK1ATML3MBTL1NPC1 | |
| SCHEMBL11491274 | 0.79 | ATM (0.60) | SMN1; SMN2MAPK1ATML3MBTL1NPC1 | |
| SCHEMBL14563985 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPK1FOLH1L3MBTL1NPC1 | |
| SCHEMBL4683971 | 0.78 | CTSS (0.43) | TAS1R3TAS1R1ATMFOLH1ALDH1A1 | |
| SCHEMBL4683972 | 0.78 | CTSS (0.43) | TAS1R3TAS1R1ATMFOLH1ALDH1A1 | |
| SCHEMBL4686341 | 0.77 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPK1ATML3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781649-A2 | SUBSTITUTED HYDANTOINS | F. Hoffmann-Roche AG (CH) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018188-A2 | SUBSTITUTED HYDANTOINS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-23 | — | — | WO | disclosed |