Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.42 |
| ▸ | ESRRG | P62508 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206105 | 0.81 | NAMPT (0.40) | HDAC1NAMPT | |
| SCHEMBL24671113 | 0.79 | TP53 (0.49) | TP53SMN1; SMN2ESR1ESRRGHDAC3 | |
| SCHEMBL29803912 | 0.79 | TP53 (0.49) | TP53SMN1; SMN2ESR1ESRRGHDAC3 | |
| SCHEMBL24669946 | 0.79 | TP53 (0.42) | TP53SMN1; SMN2ESR1ESRRGESR2 | |
| SCHEMBL29803733 | 0.79 | MAPKAPK2 (0.52) | TP53SMN1; SMN2ESR1ESRRGNPC1 | |
| Hydrochloric Acid SCHEMBL2827994 | 0.78 | HDAC1 (0.54) | HDAC3HDAC2HDAC1MAPK1HDAC4 | |
| SCHEMBL24670348 | 0.76 | TP53 (0.46) | TP53SMN1; SMN2ESR1ESRRGNPC1 | |
| Hydrochloric Acid SCHEMBL29803461 | 0.76 | TP53 (0.46) | TP53SMN1; SMN2ESR1ESRRGNPC1 | |
| SCHEMBL24671415 | 0.75 | MAPKAPK2 (0.42) | TP53SMN1; SMN2ESR1ESRRGNPC1 | |
| SCHEMBL24671298 | 0.75 | ESRRG (0.43) | TP53ESR1ESRRGMAPTESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501508-B1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | EP | disclosed |
| US-20050222410-A1 | Inhibitors of histone deacetylase | ASTRAZENECA AB (SE) | 2005-10-06 | — | — | US | disclosed |
| CN-1662236-A | Inhibitors of histone deacetylase | ASTRAZENECA AB (SE) | 2005-08-31 | — | — | CN | disclosed |
| EP-1501508-A1 | INHIBITORS OF HISTONE DEACETYLASE | Astrazeneca AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003092686-A1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222410-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | TP53 2225/4885SMN1; SMN2 3288/4885ESR1 4741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.