Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215067 | 0.88 | TNF (0.36) | UTS2RCHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL3168161 | 0.87 | CHRM2 (0.43) | UTS2RCHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL3183784 | 0.87 | CHRM2 (0.43) | UTS2RCHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL3176038 | 0.87 | CHRM2 (0.43) | UTS2RCHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL5112850 | 0.78 | MEN1 (0.46) | UTS2RGPR119MEN1KMT2A | |
| SCHEMBL3173426 | 0.74 | GPR119 (0.39) | CHRM2CHRM1CHRM3GPR119MEN1 | |
| SCHEMBL3173421 | 0.74 | GPR119 (0.39) | CHRM2CHRM1CHRM3GPR119MEN1 | |
| SCHEMBL3168339 | 0.74 | CHRM2 (0.41) | CHRM2CHRM1CHRM3GPR119P2RX4 | |
| SCHEMBL3168332 | 0.74 | CHRM2 (0.41) | CHRM2CHRM1CHRM3GPR119P2RX4 | |
| SCHEMBL3184310 | 0.73 | GPR119 (0.49) | CHRM2CHRM1CHRM3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833826-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006069276-A2 | TRICYCLIC ō-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | disclosed |