Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229177 | 0.90 | CCNA2 (0.50) | MAPTADORA1CDK2CCNA2CCNA1 | |
| SCHEMBL5230295 | 0.85 | CCNA2 (0.53) | MAPTADORA1CDK2CCNA2CCNA1 | |
| SCHEMBL5228664 | 0.83 | ALDH1A1 (0.52) | MAPTAPPADORA1CDK2CCNA2 | |
| SCHEMBL5230050 | 0.81 | CCNA2 (0.42) | CDK2CCNA2CCNA1SMN1; SMN2METAP2 | |
| SCHEMBL5229894 | 0.79 | CCNA2 (0.53) | MAPTCDK2CCNA2CCNA1KMT2A | |
| SCHEMBL5227704 | 0.78 | CDK2 (0.53) | CDK2CCNA2CCNA1ALDH1A1KDM4E | |
| SCHEMBL5227766 | 0.78 | CDK2 (0.52) | CDK2CCNA2CCNA1ALDH1A1CCNE1 | |
| SCHEMBL5226943 | 0.78 | CDK2 (0.54) | CDK2CCNA2CCNA1KMT2AROCK2 | |
| SCHEMBL5230389 | 0.78 | CCNA2 (0.54) | CDK2CCNA2CCNA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5225569 | 0.77 | CCNA2 (0.52) | CDK2CCNA2CCNA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478357-B1 | TRICYCLIC PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PFIZER ITALIA SRL (IT) | 2007-01-31 | — | — | EP | claimed |