SCHEMBL5226713

SCHEMBL5226713

CN(c1ccc2c(c1)nc(N(C(=O)O)c1noc(C(C)(C)C)c1C(C)(C)C)n2C)c1ccnc(Cl)n1

nearest known ligand 0.34

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
KDR P35968 1/20 0.34
HDAC6 Q9UBN7 3/20 0.33
HDAC3 O15379 1/20 0.31
HDAC4 P56524 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC10 Q969S8 1/20 0.31
HDAC11 Q96DB2 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
HDAC9 Q9UKV0 1/20 0.31
HDAC5 Q9UQL6 1/20 0.31
SLC2A1 P11166 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5226042 0.84 KDR (0.37) CYP3A4CYP2D6CYP2C9CYP2C19KDR
SCHEMBL5228803 0.82 KDR (0.40) CYP3A4CYP2D6CYP2C9CYP2C19KDR
SCHEMBL5222688 0.82 KDR (0.40) CYP3A4CYP2D6CYP2C9CYP2C19KDR
SCHEMBL5225575 0.81 KDR (0.36) CYP3A4CYP2D6CYP2C9CYP2C19KDR
SCHEMBL5224254 0.80 KDR (0.38) CYP3A4CYP2D6CYP2C9CYP2C19KDR
SCHEMBL5226754 0.80 KDR (0.39) CYP3A4CYP2D6CYP2C9CYP2C19KDR
SCHEMBL4976870 0.80 SLC2A1 (0.34) CYP3A4CYP2D6CYP2C9CYP2C19KDR
SCHEMBL5224606 0.79 KDR (0.37) CYP3A4CYP2D6CYP2C9CYP2C19KDR
SCHEMBL5226700 0.78 SLC2A1 (0.33) CYP3A4CYP2D6CYP2C9CYP2C19KDR
SCHEMBL4978772 0.77 KDR (0.37) CYP3A4CYP2D6CYP2C9CYP2C19KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1487824-B1 DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS SMITHKLINE BEECHAM CORP (US) 2007-06-20 EP disclosed