Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.39 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.37 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260109 | 0.92 | TEK (0.41) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5194635 | 0.92 | MAPK14 (0.50) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5185055 | 0.87 | TEK (0.48) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL31026230 | 0.82 | TSHR (0.48) | TP53CRHR1 | |
| SCHEMBL5196834 | 0.81 | NPSR1 (0.43) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5194905 | 0.80 | MAPK14 (0.50) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5196919 | 0.79 | MAPK14 (0.52) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5197084 | 0.79 | TEK (0.46) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5194356 | 0.79 | MAPK14 (0.42) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5197308 | 0.78 | TEK (0.45) | TEKMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |