Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GCGR | P47871 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198537 | 0.92 | ALDH1A1 (0.37) | NPSR1KDM4EMAPK14MAPK11MAPK13 | |
| SCHEMBL5197958 | 0.91 | MAPK14 (0.38) | NPSR1KDM4EMAPK14MAPK11MAPK13 | |
| SCHEMBL5185055 | 0.85 | TEK (0.48) | MAPK14MAPK11MAPK13MAPK12NSD3 | |
| SCHEMBL5198719 | 0.84 | NPSR1 (0.44) | NPSR1KDM4EMAPK14MAPK11MAPK13 | |
| SCHEMBL5194635 | 0.83 | MAPK14 (0.50) | MAPK14MAPK11MAPK13MAPK12NSD3 | |
| SCHEMBL5226965 | 0.81 | TEK (0.43) | MAPK14MAPK11MAPK13MAPK12NSD3 | |
| SCHEMBL5194905 | 0.79 | MAPK14 (0.50) | MAPK14MAPK11MAPK13MAPK12TEK | |
| SCHEMBL5196919 | 0.78 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12TEK | |
| SCHEMBL5197084 | 0.78 | TEK (0.46) | MAPK14MAPK11MAPK13MAPK12NSD3 | |
| SCHEMBL5197308 | 0.77 | TEK (0.45) | MAPK14MAPK11MAPK13MAPK12NSD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | claimed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | claimed |
| US-20060173048-A1 | Imidazole derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2006-08-03 | — | — | US | claimed |
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173048-A1 | Imidazole derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173048-A1 | Imidazole derivatives | GRM2, GRM1, GRIN2C | NPSR1 154/4885KDM4E 1285/4885MAPK14 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.