Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 5/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224342 | 0.85 | HDAC1 (0.70) | HDAC3HDAC2HDAC1BCHEHDAC4 | |
| SCHEMBL5225324 | 0.85 | HDAC3 (0.57) | HDAC3HDAC2HDAC1CCR5BCHE | |
| SCHEMBL6346948 | 0.77 | HDAC3 (0.49) | HDAC3HDAC2HDAC1CCR5BCHE | |
| SCHEMBL28350179 | 0.74 | KMT2A (0.53) | HDAC3HDAC2HDAC1HDAC4HDAC7 | |
| SCHEMBL5224592 | 0.72 | HDAC1 (0.72) | HDAC3HDAC2HDAC1HDAC4HDAC7 | |
| SCHEMBL5224146 | 0.70 | HDAC3 (0.59) | HDAC3HDAC2HDAC1HDAC4HDAC7 | |
| SCHEMBL6587418 | 0.69 | AURKB (0.77) | ALDH1A1MAPTNPBWR1MCHR1L3MBTL1 | |
| SCHEMBL27739911 | 0.69 | OPRM1 (0.71) | ALDH1A1MAPTNPBWR1MCHR1L3MBTL1 | |
| SCHEMBL28350182 | 0.69 | SMN1; SMN2 (0.55) | HDAC3HDAC2HDAC1CCR5HDAC4 | |
| SCHEMBL4413158 | 0.68 | HDAC1 (0.52) | HDAC3HDAC2HDAC1HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501508-B1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | EP | disclosed |
| EP-1501508-A1 | INHIBITORS OF HISTONE DEACETYLASE | Astrazeneca AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003092686-A1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2003-11-13 | — | — | WO | disclosed |