Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 9/20 | 0.52 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227257 | 0.90 | SPHK1 (0.52) | SPHK1SPHK2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5221713 | 0.81 | SPHK1 (0.66) | SPHK1SPHK2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5221700 | 0.81 | SPHK1 (0.66) | SPHK1SPHK2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5222060 | 0.76 | KCNH2 (0.45) | KDM4ECHKACXCR1ALDH1A1LMNA | |
| SCHEMBL5222076 | 0.76 | KCNH2 (0.45) | KDM4ECHKACXCR1ALDH1A1LMNA | |
| SCHEMBL5224224 | 0.75 | SPHK2 (0.47) | SPHK1SPHK2SMN1; SMN2 | |
| SCHEMBL5223518 | 0.75 | SPHK2 (0.47) | SPHK1SPHK2SMN1; SMN2 | |
| SCHEMBL5223511 | 0.75 | SPHK2 (0.47) | SPHK1SPHK2SMN1; SMN2 | |
| SCHEMBL5225958 | 0.75 | SMN1; SMN2 (0.59) | KDM4ECHKAALDH1A1LMNAMAPT | |
| SCHEMBL5225149 | 0.74 | SMN1; SMN2 (0.61) | KDM4EALDH1A1LMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771449-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-04-11 | — | — | EP | claimed |
| WO-2006011043-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-02-02 | — | — | WO | claimed |
| US-20060019998-A1 | Histamine-3 receptor antagonist | PFIZER INC | 2006-01-26 | — | — | US | claimed |
| US-20060019998-A1 | Histamine-3 receptor antagonist | PFIZER INC | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019998-A1 | Histamine-3 receptor antagonist | HRH3, HRH4, HRH2 | SPHK1 943/4885SPHK2 1144/4885KDM4E 3277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.