Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28957460 | 0.99 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9AHRH3HRH4 | |
| SCHEMBL5225958 | 0.99 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9AHRH3HRH4 | |
| SCHEMBL5224880 | 0.88 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AHRH3CYP2D6 | |
| SCHEMBL5224071 | 0.86 | S1PR1 (0.47) | SMN1; SMN2NPC1RAB9AHRH3CYP2D6 | |
| SCHEMBL5223197 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ACYP2D6CYP2C19 | |
| SCHEMBL7070577 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AHRH3CYP2D6 | |
| SCHEMBL5225059 | 0.84 | RAB9A (0.46) | SMN1; SMN2NPC1RAB9AHRH3HRH4 | |
| SCHEMBL5225048 | 0.84 | RAB9A (0.46) | SMN1; SMN2NPC1RAB9AHRH3HRH4 | |
| SCHEMBL5928064 | 0.83 | KCNH2 (0.46) | SMN1; SMN2NPC1RAB9AHRH3CYP2D6 | |
| SCHEMBL5225628 | 0.83 | ALDH1A1 (0.58) | SMN1; SMN2NPC1RAB9ACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771449-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-04-11 | — | — | EP | claimed |
| WO-2006011043-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-02-02 | — | — | WO | claimed |
| US-20060019998-A1 | Histamine-3 receptor antagonist | PFIZER INC | 2006-01-26 | — | — | US | claimed |
| EP-1771449-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006011043-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-02-02 | — | — | WO | disclosed |
| US-20060019998-A1 | Histamine-3 receptor antagonist | PFIZER INC | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019998-A1 | Histamine-3 receptor antagonist | HRH3, HRH4, HRH2 | SMN1; SMN2 1870/4885NPC1 616/4885RAB9A 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.