Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | GGT1 | P19440 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30050310 | 0.84 | KCNK3 (0.46) | PTGER1TSHRMAPK1HPGDKDM4E | |
| SCHEMBL4888341 | 0.84 | KCNK3 (0.46) | PTGER1TSHRMAPK1HPGDKDM4E | |
| SCHEMBL282647 | 0.83 | KDM4E (0.58) | TSHRMAPK1HPGDKDM4EHSD17B10 | |
| SCHEMBL1508738 | 0.83 | PTGER1 (0.43) | PTGER1TSHRMAPK1HPGDKDM4E | |
| Bicarbonate SCHEMBL238203 | 0.81 | KDM4E (0.56) | TSHRMAPK1HPGDKDM4EHSD17B10 | |
| SCHEMBL6559414 | 0.81 | KDM4E (0.56) | TSHRMAPK1HPGDKDM4EHSD17B10 | |
| SCHEMBL8645581 | 0.81 | KDM4E (0.56) | TSHRMAPK1HPGDKDM4EHSD17B10 | |
| SCHEMBL16953413 | 0.81 | KCNH2 (0.36) | TSHRMAPK1HPGDKDM4EHSD17B10 | |
| Bicarbonate SCHEMBL20694826 | 0.81 | KDM4E (0.56) | TSHRMAPK1HPGDKDM4EHSD17B10 | |
| Bicarbonate SCHEMBL29943603 | 0.81 | KDM4E (0.56) | TSHRMAPK1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | disclosed |