Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ESRRG | P62508 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215100 | 0.83 | PARP1 (0.53) | OPRK1MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL3107249 | 0.79 | ALDH1A1 (0.55) | MAPTALDH1A1KDM4EGLAGAA | |
| SCHEMBL3957425 | 0.76 | TSHR (0.58) | CNR2OPRM1OPRD1OPRK1ESRRG | |
| Diethylaniline SCHEMBL28333434 | 0.73 | MEN1 (0.59) | CNR2ESRRGMAPTALDH1A1KDM4E | |
| SCHEMBL7161448 | 0.73 | PTGS1 (0.70) | MAPTALDH1A1KDM4EMEN1MAPK1 | |
| SCHEMBL18713695 | 0.71 | HDAC4 (0.54) | MAPTALDH1A1KDM4EGAAMAPK1 | |
| SCHEMBL30154821 | 0.70 | PARP1 (0.57) | MAPTALDH1A1KDM4EMAPK1PTGS1 | |
| SCHEMBL84456 | 0.70 | PARP1 (0.57) | MAPTALDH1A1KDM4EMAPK1PTGS1 | |
| SCHEMBL11217301 | 0.70 | ALDH1A1 (0.54) | MAPTALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL20032296 | 0.70 | PARP1 (0.52) | MAPTMEN1KMT2ACYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869055-A1 | NOVEL 5,7-DISUBSTITUTED Ý1,3¨THIAZOLOÝ4,5-D¨PYRIMIDIN-2(3H)-ONE DERIVATIVES | AstraZeneca AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006107257-A1 | NOVEL 5,7-DISUBSTITUTED [1,3]THIAZOLO[4,5-D]PYRIMIDIN-2(3H)-ONE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-10-12 | — | — | WO | disclosed |