Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 7/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227191 | 0.87 | PARP1 (0.39) | DPP4DPP7DPP8DPP9PARP1 | |
| SCHEMBL5228676 | 0.81 | DPP4 (0.41) | TACR1DPP4DPP7DPP8DPP9 | |
| SCHEMBL5227629 | 0.80 | DPP4 (0.37) | DPP4DPP7DPP8DPP9NR1H2 | |
| SCHEMBL5228855 | 0.75 | DPP4 (0.49) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL29229139 | 0.73 | KLK7 (0.46) | DPP4PARP1KLK7MEN1KMT2A | |
| SCHEMBL29229186 | 0.73 | KLK7 (0.46) | DPP4PARP1KLK7MEN1KMT2A | |
| SCHEMBL28549464 | 0.72 | PARP1 (0.46) | PARP1KLK7NR1H2NR1H3JAK2 | |
| SCHEMBL7921498 | 0.71 | KLK7 (0.47) | PARP1KLK7NR1H2NR1H3JAK2 | |
| SCHEMBL7921496 | 0.71 | KLK7 (0.47) | PARP1KLK7NR1H2NR1H3JAK2 | |
| SCHEMBL1341573 | 0.70 | PARP1 (0.40) | TACR1PARP1KLK7NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554280-B1 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO INC (US) | 2007-08-15 | — | — | EP | disclosed |