Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 16/20 | 0.44 |
| ▸ | NOS1 | P29475 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3558024 | 0.90 | NOS2 (0.43) | NOS2NOS1USP2CD38 | |
| SCHEMBL3558453 | 0.89 | NOS2 (0.43) | NOS2NOS1KDM4EHSD17B10USP2 | |
| SCHEMBL5320270 | 0.81 | NOS2 (0.40) | NOS2NOS1CD38 | |
| SCHEMBL3566595 | 0.81 | NOS2 (0.59) | NOS2NOS1KDM4EHSD17B10USP2 | |
| SCHEMBL27712178 | 0.80 | NOS2 (0.43) | NOS2NOS1CD38 | |
| SCHEMBL3564331 | 0.79 | NOS2 (0.41) | NOS2NOS1KDM4ETSHRMAPK1 | |
| SCHEMBL3564512 | 0.77 | NOS2 (0.40) | NOS2NOS1KDM4ETSHRMAPK1 | |
| SCHEMBL3566417 | 0.77 | NOS2 (0.42) | NOS2NOS1USP2CD38 | |
| SCHEMBL3563497 | 0.77 | NOS2 (0.41) | NOS2NOS1KDM4EMEN1ALDH1A1 | |
| SCHEMBL3559652 | 0.76 | NOS2 (0.42) | NOS2NOS1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817030-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | Kalypsys, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006060424-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | KALYPSYS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |