Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MYT1 | Q01538 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229227 | 1.00 | HDAC4 (0.32) | HDAC4STSKDM1AGPR119KDM4E | |
| SCHEMBL5232203 | 0.84 | DPP4 (0.33) | KMT2A | |
| SCHEMBL5232199 | 0.84 | DPP4 (0.33) | KMT2A | |
| SCHEMBL3133058 | 0.80 | HDAC4 (0.35) | HDAC4STSKDM1AGPR119KDM4E | |
| SCHEMBL3133282 | 0.69 | DPP4 (0.46) | HDAC4GPR119MAPTMYT1ALDH1A1 | |
| SCHEMBL5228855 | 0.68 | DPP4 (0.49) | ALDH1A1 | |
| SCHEMBL5229207 | 0.65 | DPP4 (0.53) | MEN1KMT2AALDH1A1 | |
| SCHEMBL5228676 | 0.65 | DPP4 (0.41) | MEN1KMT2AALDH1A1 | |
| SCHEMBL5228869 | 0.65 | DPP4 (0.54) | MEN1KMT2AALDH1A1 | |
| SCHEMBL5233907 | 0.65 | DPP4 (0.54) | GPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554280-B1 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO INC (US) | 2007-08-15 | — | — | EP | disclosed |