Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 4/20 | 0.39 |
| ▸ | TNKS | O95271 | 2/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 4/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886408 | 0.89 | CYP11B2 (0.52) | HDAC2HDAC1CYP11B2PARP1TNKS | |
| SCHEMBL2884232 | 0.88 | HDAC2 (0.50) | HDAC2HDAC1CYP11B2ACACBSCD5 | |
| SCHEMBL4299226 | 0.84 | CYP11B2 (0.48) | HDAC2HDAC1CYP11B2PARP1TNKS | |
| SCHEMBL25024580 | 0.84 | HDAC2 (0.49) | HDAC2HDAC1CYP11B2PARP1TNKS | |
| SCHEMBL4303345 | 0.83 | CYP11B2 (0.52) | HDAC2HDAC1CYP11B2ACACBSCD5 | |
| SCHEMBL2886266 | 0.83 | CYP11B2 (0.52) | HDAC2HDAC1CYP11B2ACACBSCD5 | |
| SCHEMBL29772893 | 0.78 | CYP11B2 (0.50) | HDAC2HDAC1CYP11B2PARP1TNKS | |
| SCHEMBL24628132 | 0.78 | CYP11B2 (0.50) | HDAC2HDAC1CYP11B2PARP1TNKS | |
| SCHEMBL22165053 | 0.78 | NR1H2 (0.46) | HDAC2HDAC1CYP11B2PARP1HRH3 | |
| SCHEMBL31548466 | 0.78 | NR1H2 (0.46) | HDAC2HDAC1CYP11B2PARP1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781663-A2 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | Sanofi-Aventis Deutschland GmbH (DE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018280-A2 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-02-23 | — | — | WO | disclosed |