Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 14/20 | 0.79 |
| ▸ | CDK19 | Q9BWU1 | 7/20 | 0.68 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.62 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.62 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.62 |
| ▸ | GSK3A | P49840 | 1/20 | 0.62 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.58 |
| ▸ | IKBKB | O14920 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229194 | 0.95 | CDK8 (0.80) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL4657878 | 0.90 | CDK8 (0.97) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL5234827 | 0.88 | CDK8 (1.00) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL5236246 | 0.88 | CDK8 (1.00) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL4656716 | 0.88 | CDK8 (1.00) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL4659310 | 0.87 | CDK8 (0.79) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL4657870 | 0.86 | CDK8 (0.77) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL4659279 | 0.86 | CDK8 (0.77) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL5240724 | 0.85 | CDK8 (0.76) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| Hydrochloric Acid SCHEMBL5233358 | 0.85 | CDK8 (0.76) | CDK8CDK19RIOK2CSNK1A1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070219234-A1 | Thienopyridine Derivatives | SANKYO COMPANY, LIMITED (JP) | 2007-09-20 | — | — | US | disclosed |
| CN-1968954-A | Thienopyridine Derivatives | SANKYO CO (JP) | 2007-05-23 | — | — | CN | disclosed |
| EP-1764367-A1 | THIENOPYRIDINE DERIVATIVES | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219234-A1 | Thienopyridine Derivatives | RASGRP1, NRAS, HRH3 | CDK8 2017/4885CDK19 1842/4885RIOK2 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.