Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 17/20 | 0.65 |
| ▸ | PGR | P06401 | 10/20 | 0.58 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229542 | 1.00 | AR (0.65) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5231908 | 1.00 | AR (0.65) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5232384 | 0.85 | AR (0.71) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5232382 | 0.85 | AR (0.71) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5232387 | 0.85 | AR (0.71) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL14409284 | 0.85 | AR (0.71) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5230657 | 0.84 | AR (0.66) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL14561713 | 0.84 | AR (0.66) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5230663 | 0.84 | AR (0.66) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5230650 | 0.84 | AR (0.66) | ARPGRNR3C2NR3C1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1439841-B1 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | MERCK & CO INC (US) | 2007-09-19 | — | — | EP | claimed |
| US-7196076-B2 | Androgen receptor modulators and methods of use thereof | MERCK & CO., INC. (US) | 2007-03-27 | — | — | US | claimed |
| US-20040198717-A1 | Androgen receptor modulators and methods of use thereof | MERCK SHARP & DOHME CORP. | 2004-10-07 | — | — | US | claimed |
| EP-1439841-B1 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | MERCK & CO INC (US) | 2007-09-19 | — | — | EP | disclosed |
| EP-1439841-B1 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | MERCK & CO INC (US) | 2007-09-19 | — | — | EP | disclosed |
| US-7196076-B2 | Androgen receptor modulators and methods of use thereof | MERCK & CO., INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196076-B2 | Androgen receptor modulators and methods of use thereof | MERCK & CO., INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196076-B2 | Androgen receptor modulators and methods of use thereof | MERCK & CO., INC. (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1439841-A4 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | MERCK & CO INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-20040198717-A1 | Androgen receptor modulators and methods of use thereof | MERCK SHARP & DOHME CORP. | 2004-10-07 | — | — | US | disclosed |
| EP-1439841-A2 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | Merck & Co., Inc. (US) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003034987-A2 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | MERCK & CO., INC. (US) | 2003-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198717-A1 | Androgen receptor modulators and methods of use thereof | AR, SHBG, FSHR | AR 1/4885PGR 59/4885NR3C2 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.