Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.36 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409424 | 0.89 | MAPT (0.47) | TGFBR1MAPK14TP53NPSR1CACNA1B | |
| SCHEMBL5239707 | 0.89 | TGFBR1 (0.46) | TGFBR1MAPK14THRBGRM4KDR | |
| SCHEMBL5235670 | 0.87 | TGFBR1 (0.45) | TGFBR1MAPK14THRBGRM4KDR | |
| SCHEMBL5229861 | 0.86 | TGFBR1 (0.45) | TGFBR1MAPK14THRBGRM4KDR | |
| SCHEMBL5238981 | 0.85 | TGFBR1 (0.47) | TGFBR1MAPK14THRBGRM4KDR | |
| SCHEMBL5238125 | 0.85 | TGFBR1 (0.47) | TGFBR1MAPK14THRBGRM4KDR | |
| SCHEMBL5234631 | 0.84 | TGFBR1 (0.47) | TGFBR1MAPK14THRBGRM4KDR | |
| SCHEMBL5231594 | 0.84 | TGFBR1 (0.49) | TGFBR1MAPK14THRBKDRGAK | |
| SCHEMBL5236664 | 0.83 | TGFBR1 (0.46) | TGFBR1MAPK14THRBGRM4KDR | |
| SCHEMBL5239070 | 0.82 | TGFBR1 (0.49) | TGFBR1MAPK14THRBKDRGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | claimed |