Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.71 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.61 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GOT1 | P17174 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2944815 | 0.92 | MGAM (0.76) | MGAMCYP19A1RAD51NR3C1PGR | |
| SCHEMBL2944131 | 0.87 | MGAM (0.69) | MGAMCYP19A1RAD51NR3C1NR3C2 | |
| SCHEMBL2952518 | 0.87 | MGAM (0.80) | MGAMCYP19A1RAD51NR3C1NR3C2 | |
| SCHEMBL2951061 | 0.85 | MGAM (0.70) | MGAMCYP19A1RAD51NR3C1PGR | |
| SCHEMBL2952890 | 0.84 | MGAM (0.75) | MGAMCYP19A1RAD51NR3C1MEN1 | |
| SCHEMBL2947791 | 0.83 | MGAM (0.84) | MGAMCYP19A1RAD51NR3C1NR3C2 | |
| SCHEMBL5228650 | 0.83 | CYP19A1 (0.70) | MGAMCYP19A1RAD51MEN1KMT2A | |
| SCHEMBL2951081 | 0.81 | MGAM (0.67) | MGAMCYP19A1RAD51NR3C1MEN1 | |
| SCHEMBL2949600 | 0.81 | NR3C1 (0.67) | MGAMCYP19A1RAD51NR3C1MEN1 | |
| SCHEMBL2951564 | 0.81 | MGAM (0.66) | MGAMCYP19A1RAD51NR3C1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |