Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 4/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 3/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | GMNN | O75496 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8118476 | 0.99 | ADORA1 (1.00) | ADORA2BADORA2AADORA1MEN1GMNN | |
| SCHEMBL9645551 | 0.96 | ADORA1 (0.95) | ADORA2BADORA2AADORA1MEN1GMNN | |
| SCHEMBL5227560 | 0.93 | ADORA1 (0.90) | ADORA2BADORA2AADORA1MEN1GMNN | |
| SCHEMBL8126083 | 0.86 | ADORA1 (0.77) | ADORA2BADORA2AADORA1MEN1GMNN | |
| SCHEMBL8580800 | 0.85 | ADORA1 (0.76) | ADORA2BADORA2AADORA1MEN1GMNN | |
| SCHEMBL5231623 | 0.84 | ADORA1 (0.73) | ADORA2BADORA2AADORA1MEN1GMNN | |
| SCHEMBL4623484 | 0.83 | ADORA1 (1.00) | ADORA2BADORA2AADORA1MEN1GMNN | |
| SCHEMBL8578121 | 0.83 | ADORA1 (0.72) | ADORA2BADORA2AADORA1MEN1GMNN | |
| 1,3-Dipropyl-8-Cyclopentylxanthine [Dpcpx] SCHEMBL382422 | 0.82 | ADORA1 (1.00) | ADORA2BADORA2AADORA1MEN1GMNN | |
| SCHEMBL7378595 | 0.81 | ADORA1 (0.69) | ADORA2BADORA2AADORA1MEN1GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1092435-B1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO KK (JP) | 2007-04-04 | — | — | EP | disclosed |
| US-6489331-B1 | A CONDENSED PURINE DERIVATIVE AS AN ACTIVE INGREDIENT AS AN ENHANCER OF INSULIN SECRETION AND A MEDICAMENT FOR THE TREATMENT OF DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| EP-1092435-A1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-18 | — | — | EP | disclosed |