Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 9/20 | 0.90 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.88 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.88 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645551 | 0.95 | ADORA1 (0.95) | ADORA1ADORA2AADORA2BMEN1GMNN | |
| SCHEMBL8118476 | 0.95 | ADORA1 (1.00) | ADORA1ADORA2AADORA2BMEN1GMNN | |
| SCHEMBL5229734 | 0.93 | ADORA2B (1.00) | ADORA1ADORA2AADORA2BMEN1GMNN | |
| SCHEMBL7378595 | 0.86 | ADORA1 (0.69) | ADORA1ADORA2AADORA2BMEN1GMNN | |
| SCHEMBL7425220 | 0.86 | ADORA1 (0.69) | ADORA1ADORA2AADORA2BMEN1GMNN | |
| SCHEMBL4621677 | 0.82 | ADORA1 (1.00) | ADORA1ADORA2AADORA2BMEN1GMNN | |
| SCHEMBL5231623 | 0.82 | ADORA1 (0.73) | ADORA1ADORA2AADORA2BMEN1GMNN | |
| SCHEMBL8126083 | 0.82 | ADORA1 (0.77) | ADORA1ADORA2AADORA2BMEN1GMNN | |
| SCHEMBL8580800 | 0.81 | ADORA1 (0.76) | ADORA1ADORA2AADORA2BMEN1GMNN | |
| SCHEMBL7427017 | 0.81 | ADORA1 (0.78) | ADORA1ADORA2AADORA2BMEN1GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280417-A1 | XANTHINE-SUBSTITUTED ALKYNYL CARBAMATES/REVERSE CARBAMATES AS A2B ANTAGONISTS | Lewis and Clark Pharmaceuticals, Inc. (US) | 2018-02-14 | — | — | EP | disclosed |
| WO-2016164838-A1 | XANTHINE-SUBSTITUTED ALKYNYL CARBAMATES/REVERSE CARBAMATES AS A2B ANTAGONISTS | LEWIS AND CLARK PHARMACEUTICALS, INC. (US) | 2016-10-13 | — | — | WO | disclosed |
| EP-1092435-B1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO KK (JP) | 2007-04-04 | — | — | EP | disclosed |
| US-6489331-B1 | A CONDENSED PURINE DERIVATIVE AS AN ACTIVE INGREDIENT AS AN ENHANCER OF INSULIN SECRETION AND A MEDICAMENT FOR THE TREATMENT OF DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| EP-1092435-A1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-18 | — | — | EP | disclosed |
| EP-0256692-B1 | 6-THIOXANTHINES | Euroceltique S.A. (LU) | 1992-09-16 | — | — | EP | disclosed |
| US-5010081-A | Bronchodilator agents | EUROCELTIQUE, S.A. (LU) | 1991-04-23 | — | — | US | disclosed |
| US-4925847-A | BRONCHODILATORS | EUROCELTIQUE, S.A. (LU) | 1990-05-15 | — | — | US | disclosed |
| EP-0256692-A2 | 6-Thioxanthines | Euroceltique S.A. (LU) | 1988-02-24 | — | — | EP | disclosed |
| US-4546182-A | TREATMENT OF RESPIRATORY AND CARDIO-VASCULAR DISORDERS | AKTIEBOLAGET DRACO (SE) | 1985-10-08 | — | — | US | disclosed |