Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.78 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228614 | 1.00 | MAPK14 (0.78) | MAPK14MAPK8MAPK9CDK2CCNE1 | |
| SCHEMBL5263415 | 0.91 | MAPK14 (0.73) | MAPK14MAPK8MAPK9CDK2CCNE1 | |
| SCHEMBL5263417 | 0.91 | MAPK14 (0.73) | MAPK14MAPK8MAPK9CDK2CCNE1 | |
| SCHEMBL5229413 | 0.87 | MAPK14 (1.00) | MAPK14MAPK8MAPK9MAPK10FGFR4 | |
| SCHEMBL5232688 | 0.87 | MAPK14 (1.00) | MAPK14MAPK8MAPK9MAPK10FGFR4 | |
| SCHEMBL5229406 | 0.87 | MAPK14 (1.00) | MAPK14MAPK8MAPK9MAPK10FGFR4 | |
| SCHEMBL5232245 | 0.87 | MAPK14 (0.82) | MAPK14MAPK8MAPK10CDK7CDK9 | |
| SCHEMBL5232252 | 0.87 | MAPK14 (0.82) | MAPK14MAPK8MAPK10CDK7CDK9 | |
| SCHEMBL5232763 | 0.86 | MAPK14 (0.80) | MAPK14MAPK8MAPK9CDK2CCNE1 | |
| SCHEMBL5232230 | 0.86 | MAPK14 (0.80) | MAPK14MAPK8CDK2CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228070-B1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | HOFFMANN LA ROCHE (CH) | 2007-02-07 | — | — | EP | disclosed |
| US-6451804-B1 | Heteroalkylamino-substituted bicyclic nitrogen heterocycles | SYNTEX (U.S.A.) LLC | 2002-09-17 | — | — | US | disclosed |
| EP-1228070-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001029042-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |