Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.80 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | WEE1 | P30291 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232763 | 0.90 | MAPK14 (0.80) | MAPK14MAPK8MAPK1FGFR4CDK1 | |
| SCHEMBL5232245 | 0.89 | MAPK14 (0.82) | MAPK14MAPK8FGFR4MAPK7 | |
| SCHEMBL5229413 | 0.89 | MAPK14 (1.00) | MAPK14MAPK8MAPK1FGFR4MAPK7 | |
| SCHEMBL5232252 | 0.89 | MAPK14 (0.82) | MAPK14MAPK8FGFR4MAPK7 | |
| SCHEMBL5229406 | 0.89 | MAPK14 (1.00) | MAPK14MAPK8MAPK1FGFR4MAPK7 | |
| SCHEMBL5230085 | 0.89 | MAPK14 (0.79) | MAPK14MAPK8MAPK1LCK | |
| SCHEMBL5232688 | 0.89 | MAPK14 (1.00) | MAPK14MAPK8MAPK1FGFR4MAPK7 | |
| SCHEMBL5239181 | 0.88 | MAPK14 (0.81) | MAPK14MAPK8MAPK1FGFR4MAPK7 | |
| SCHEMBL5228614 | 0.86 | MAPK14 (0.78) | MAPK14MAPK8FGFR4CDK1CDK4 | |
| SCHEMBL5230080 | 0.86 | MAPK14 (0.78) | MAPK14MAPK8FGFR4CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228070-B1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | HOFFMANN LA ROCHE (CH) | 2007-02-07 | — | — | EP | disclosed |
| US-6451804-B1 | Heteroalkylamino-substituted bicyclic nitrogen heterocycles | SYNTEX (U.S.A.) LLC | 2002-09-17 | — | — | US | disclosed |
| EP-1228070-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001029042-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |