Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.81 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.81 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.81 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228842 | 0.91 | GABRG2 (0.80) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL5231268 | 0.91 | GABRG2 (0.81) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL5228494 | 0.90 | GABRG2 (0.79) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL5229266 | 0.90 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL5229617 | 0.88 | GABRG2 (0.81) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL2655013 | 0.85 | GABRG2 (0.80) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL5231735 | 0.85 | GABRG2 (0.81) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL2655514 | 0.85 | GABRG2 (0.81) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL5227241 | 0.84 | GABRG2 (0.64) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL5230593 | 0.83 | GABRG2 (0.66) | GABRG2GABRB3GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121361-B1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2007-08-29 | — | — | EP | claimed |
| EP-1121361-B1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2007-08-29 | — | — | EP | disclosed |
| US-6476030-B1 | Pyrazolo-triazine derivatives as ligands for GABA receptors | MERCK SHARP & DOHME LTD. | 2002-11-05 | — | — | US | disclosed |