Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227753 | 0.93 | TACR1 (0.40) | ALDH1A1SMN1; SMN2KMT2AMEN1TACR1 | |
| SCHEMBL5228863 | 0.84 | TACR1 (0.38) | KMT2ATACR1TSHRITGB2ICAM1 | |
| SCHEMBL5233229 | 0.83 | TACR1 (0.42) | TACR1 | |
| SCHEMBL5228486 | 0.83 | TACR1 (0.44) | TACR1HPGDTSHR | |
| SCHEMBL5228816 | 0.83 | TACR1 (0.40) | ALDH1A1KMT2AMEN1TACR1TSHR | |
| SCHEMBL5225834 | 0.83 | TACR1 (0.44) | TACR1CASP1 | |
| SCHEMBL5227311 | 0.82 | TACR1 (0.42) | TACR1HPGDTSHRCASP1 | |
| SCHEMBL5225571 | 0.82 | TACR1 (0.40) | TACR1CASP1 | |
| SCHEMBL5232458 | 0.82 | TACR1 (0.40) | HSD17B10TDP1KMT2AMEN1TACR1 | |
| SCHEMBL5226991 | 0.82 | TACR1 (0.40) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496059-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2007-08-15 | — | — | EP | disclosed |
| EP-1496059-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2007-08-15 | — | — | EP | disclosed |
| US-7064119-B2 | Fused bicyclic pyrimidine derivatives | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2006-06-20 | — | — | US | disclosed |
| US-20050159409-A1 | Fused bicyclic pyrimidine derivatives | KYORIN PHARMACEUTICAL CO. LTD. (JP) | 2005-07-21 | — | — | US | disclosed |
| EP-1496059-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | Kyorin Pharmaceutical Co., Ltd. (JP) | 2005-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159409-A1 | Fused bicyclic pyrimidine derivatives | BDKRB1, BDKRB2, TACR1 | HSD17B10 4447/4885TDP1 3526/4885IGF1R 1695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.