Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230189 | 0.82 | MAPT (0.41) | MAPTCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL15761595 | 0.74 | MAPK1 (0.52) | MAPTCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL25012803 | 0.71 | P2RX1 (0.46) | MAPTCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL30233704 | 0.71 | P2RX1 (0.46) | MAPTCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL20421281 | 0.71 | LMNA (0.54) | MAPTCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL30233930 | 0.70 | P2RX1 (0.44) | MAPTCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL25012804 | 0.70 | P2RX1 (0.44) | MAPTCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL21135362 | 0.69 | PLA2G1B (0.51) | MAPTCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL15756000 | 0.69 | CYP1A2 (0.61) | MAPTCYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL15761594 | 0.69 | MAPT (0.74) | MAPTCYP1A2CYP3A4MAPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |