Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.66 |
| ▸ | DPP7 | Q9UHL4 | 11/20 | 0.64 |
| ▸ | DPP8 | Q6V1X1 | 10/20 | 0.64 |
| ▸ | DPP9 | Q86TI2 | 9/20 | 0.64 |
| ▸ | FAP | Q12884 | 8/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.58 |
| ▸ | AKT2 | P31751 | 1/20 | 0.58 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.58 |
| ▸ | FPR1 | P21462 | 4/20 | 0.54 |
| ▸ | FPR2 | P25090 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229026 | 1.00 | DPP4 (0.66) | DPP4DPP7DPP8DPP9FAP | |
| Hydrochloric Acid SCHEMBL8647667 | 0.99 | DPP4 (0.65) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL10615090 | 0.99 | DPP4 (0.65) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL7305245 | 0.99 | DPP4 (0.65) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL8390334 | 0.99 | DPP4 (0.65) | DPP4DPP7DPP8DPP9FAP | |
| Hydrochloric Acid SCHEMBL10615092 | 0.97 | DPP4 (0.63) | DPP4DPP7DPP8DPP9FAP | |
| Hydrochloric Acid SCHEMBL8993841 | 0.97 | DPP4 (0.63) | DPP4DPP7DPP8DPP9FAP | |
| Trifluoroacetic Acid SCHEMBL5155558 | 0.92 | DPP4 (0.58) | DPP4DPP7DPP8DPP9FAP | |
| Trifluoroacetic Acid SCHEMBL5151499 | 0.92 | DPP4 (0.58) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL8488107 | 0.89 | DPP4 (0.63) | DPP4DPP7DPP8DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373233-B1 | DERIVATIVES OF N-(ARYLSULFONYL)BETA-AMINOACIDS COMPRISING A SUBSTITUTED AMINOMETHYL GROUP, THE PREPARATION METHOD THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2007-09-05 | — | — | EP | disclosed |
| EP-1373233-A1 | DERIVATIVES OF N-(ARYLSULFONYL)BETA-AMINOACIDS COMPRISING A SUBSTITUTED AMINOMETHYL GROUP, THE PREPARATION METHOD THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002076964-A1 | DERIVATIVES OF N-(ARYLSULFONYL)BETA-AMINOACIDS COMPRISING A SUBSTITUTED AMINOMETHYL GROUP, THE PREPARATION METHOD THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-10-03 | — | — | WO | disclosed |
| EP-0877737-B1 | NOVEL N-(ARYLSULPHONYL)AMINO ACID DERIVATIVES HAVING BRADYKININ RECEPTOR AFFINITY | SANOFI SYNTHELABO (FR) | 2001-08-01 | — | — | EP | disclosed |
| EP-0614911-B1 | Compounds having a sulfonamide and an amidinegroup, process for preparation and pharmaceutical compositions comprising them | SANOFI SA (FR) | 1999-04-28 | — | — | EP | disclosed |
| EP-0877737-A1 | NOVEL N-(ARYLSULPHONYL)AMINO ACID DERIVATIVES HAVING BRADYKININ RECEPTOR AFFINITY | SANOFI (FR) | 1998-11-18 | — | — | EP | disclosed |
| US-5714497-A | EXHIBIT AFFINITY FOR BIOLOGICAL RECEPTORS OF NEUROPEPTIDE Y | SANOFI (FR) | 1998-02-03 | — | — | US | disclosed |
| US-5674890-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS; PSYCHOLOGICAL DISORDERS; ANTAGONISTS OF PEPTIDE Y | SANOFI (FR) | 1997-10-07 | — | — | US | disclosed |
| WO-1997025315-A1 | NOVEL N-(ARYLSULPHONYL)AMINO ACID DERIVATIVES HAVING BRADYKININ RECEPTOR AFFINITY | SANOFI (FR) | 1997-07-17 | — | — | WO | disclosed |
| US-5506258-A | EXHIBIT AFFINITY FOR THE BIOLOGICAL RECEPTORS OF NEUROPEPTIDES Y, WHICH ARE PRESENT IN THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS | ELF SANOFI (FR) | 1996-04-09 | — | — | US | disclosed |
| EP-0614911-A1 | Compounds having a sulfonamide and an amidinegroup, process for preparation and pharmaceutical compositions comprising them | SANOFI (FR) | 1994-09-14 | — | — | EP | disclosed |