Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.38 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230730 | 1.00 | SLC6A4 (0.44) | SLC6A4DPP4HTR2ASLC6A2CYP3A4 | |
| SCHEMBL28662199 | 0.85 | IDO1 (0.47) | SLC6A4DPP4CYP3A4HTTIDO1 | |
| SCHEMBL2520231 | 0.85 | IDO1 (0.47) | SLC6A4DPP4CYP3A4HTTIDO1 | |
| SCHEMBL2520228 | 0.85 | IDO1 (0.47) | SLC6A4DPP4CYP3A4HTTIDO1 | |
| Hydrochloric Acid SCHEMBL17045274 | 0.84 | IDO1 (0.49) | SLC6A4CYP3A4HTTIDO1 | |
| SCHEMBL8886789 | 0.81 | IDO1 (0.41) | SLC6A4DPP4SLC6A2CYP3A4LMNA | |
| Hydrochloric Acid SCHEMBL11695321 | 0.77 | HTR2A (0.45) | SLC6A4HTR2AIDO1ALDH1A1 | |
| SCHEMBL3128931 | 0.77 | PNMT (0.48) | SLC6A4DPP4SLC6A2CYP3A4LMNA | |
| SCHEMBL13692464 | 0.77 | HTR2A (0.54) | SLC6A4HTR2ASLC6A2LMNAHTT | |
| SCHEMBL5181445 | 0.77 | PNMT (0.48) | SLC6A4DPP4SLC6A2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1092435-B1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO KK (JP) | 2007-04-04 | — | — | EP | disclosed |
| US-6489331-B1 | A CONDENSED PURINE DERIVATIVE AS AN ACTIVE INGREDIENT AS AN ENHANCER OF INSULIN SECRETION AND A MEDICAMENT FOR THE TREATMENT OF DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| EP-1092435-A1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-18 | — | — | EP | disclosed |