Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227806 | 0.94 | GABRG2 (0.54) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL7403631 | 0.81 | GABRG2 (0.40) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL342539 | 0.80 | GABRG2 (0.42) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL6297293 | 0.79 | GABRG2 (0.36) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL6292479 | 0.77 | GABRG2 (0.43) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL5231895 | 0.76 | GABRG2 (0.51) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL5227783 | 0.76 | GABRG2 (0.52) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL6292485 | 0.75 | TDP1 (0.33) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL367826 | 0.74 | GABRG2 (0.41) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL341480 | 0.73 | GABRG2 (0.54) | GABRG2GABRB3GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121361-B1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2007-08-29 | — | — | EP | claimed |
| US-6476030-B1 | Pyrazolo-triazine derivatives as ligands for GABA receptors | MERCK SHARP & DOHME LTD. | 2002-11-05 | — | — | US | claimed |
| EP-1121361-B1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2007-08-29 | — | — | EP | disclosed |
| US-6476030-B1 | Pyrazolo-triazine derivatives as ligands for GABA receptors | MERCK SHARP & DOHME LTD. | 2002-11-05 | — | — | US | disclosed |