Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.72 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.72 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.57 |
| ▸ | ACE | P12821 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | FAP | Q12884 | 1/20 | 0.57 |
| ▸ | PREP | P48147 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228197 | 0.83 | DPP4 (1.00) | DPP4DPP8DPP7DPP9ACE | |
| Hydrochloric Acid SCHEMBL1842316 | 0.83 | DPP4 (0.98) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL5935884 | 0.80 | DPP4 (0.70) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL8325488 | 0.76 | DPP4 (0.70) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL8334998 | 0.76 | DPP4 (0.64) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL5497175 | 0.76 | DPP4 (0.63) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL12767539 | 0.75 | DPP4 (0.68) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL3389526 | 0.75 | DPP4 (0.71) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL20781026 | 0.75 | DPP4 (1.00) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL1509241 | 0.75 | DPP4 (0.71) | DPP4DPP8DPP7DPP9ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390809-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for diabetes | MERCK & CO., INC. (US) | 2008-06-24 | — | — | US | disclosed |
| EP-1554280-B1 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO INC (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1554280-B1 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO INC (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2004032836-A2 | ANTIDIABETIC BETA-AMINO HETEROCYLCIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO., INC. (US) | 2004-04-22 | — | — | WO | disclosed |