Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.52 |
| ▸ | THRB | P10828 | 7/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL408092 | 0.86 | TGFBR1 (0.55) | TGFBR1MAPK14THRB | |
| SCHEMBL412738 | 0.84 | TGFBR1 (0.59) | TGFBR1MAPK14THRB | |
| SCHEMBL5234141 | 0.81 | TGFBR1 (0.62) | TGFBR1MAPK14THRB | |
| SCHEMBL413858 | 0.76 | TGFBR1 (0.67) | TGFBR1MAPK14THRB | |
| SCHEMBL412837 | 0.75 | TGFBR1 (0.56) | TGFBR1MAPK14THRB | |
| SCHEMBL411348 | 0.75 | TGFBR1 (0.57) | TGFBR1MAPK14THRB | |
| SCHEMBL412124 | 0.75 | TGFBR1 (0.62) | TGFBR1MAPK14THRB | |
| SCHEMBL411947 | 0.74 | TGFBR1 (0.44) | TGFBR1MAPK14THRB | |
| SCHEMBL411946 | 0.74 | TGFBR1 (0.44) | TGFBR1MAPK14THRB | |
| SCHEMBL414938 | 0.73 | TGFBR1 (0.57) | TGFBR1MAPK14THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |
| US-7087626-B2 | Pyrrole derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1397364-A1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002094833-A1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2002-11-28 | — | — | WO | disclosed |