Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5935758 | 0.78 | ADORA2A (1.00) | ADORA2AADORA2BKMT2AADORA1MEN1 | |
| SCHEMBL5453936 | 0.77 | ADORA2A (1.00) | ADORA2AADORA2BKMT2AADORA1MEN1 | |
| SCHEMBL8132199 | 0.76 | ADORA2B (0.58) | ADORA2AADORA2BKMT2AADORA1MEN1 | |
| SCHEMBL5227169 | 0.75 | ADORA1 (0.65) | ADORA2AADORA2BKMT2AADORA1MEN1 | |
| SCHEMBL6093638 | 0.74 | ADORA1 (0.65) | ADORA2AADORA2BKMT2AADORA1MEN1 | |
| SCHEMBL6093414 | 0.72 | ADORA1 (0.61) | ADORA2AADORA2BKMT2AADORA1MEN1 | |
| SCHEMBL5742960 | 0.71 | ADORA2A (0.39) | ADORA2AADORA2BKMT2AADORA1MEN1 | |
| SCHEMBL8132564 | 0.69 | PDE4A (0.56) | ADORA2AADORA2BCYP1A2PMP22 | |
| SCHEMBL3229056 | 0.68 | ADORA2A (0.73) | ADORA2AADORA2BKMT2AADORA1LMNA | |
| SCHEMBL9032193 | 0.68 | PDE4A (0.55) | ADORA2AADORA2BCYP1A2PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1092435-B1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO KK (JP) | 2007-04-04 | — | — | EP | disclosed |
| US-6489331-B1 | A CONDENSED PURINE DERIVATIVE AS AN ACTIVE INGREDIENT AS AN ENHANCER OF INSULIN SECRETION AND A MEDICAMENT FOR THE TREATMENT OF DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| EP-1092435-A1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-18 | — | — | EP | disclosed |
| EP-0423805-B1 | Condensed purine derivatives | KYOWA HAKKO KOGYO KK (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-5270316-A | Condensed purine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0423805-A2 | Condensed purine derivatives | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1991-04-24 | — | — | EP | disclosed |