Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.75 |
| ▸ | THRB | P10828 | 3/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.70 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232316 | 0.91 | TGFBR1 (0.77) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL413057 | 0.88 | TGFBR1 (0.93) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL5235558 | 0.88 | TGFBR1 (0.87) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL414248 | 0.86 | TGFBR1 (0.73) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL5237670 | 0.86 | TGFBR1 (0.90) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL413601 | 0.86 | TGFBR1 (0.79) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL373239 | 0.86 | TGFBR1 (1.00) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL5238413 | 0.86 | TGFBR1 (0.71) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL3362627 | 0.85 | TGFBR1 (0.82) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL412733 | 0.85 | TGFBR1 (0.82) | TGFBR1THRBMAPK14TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |