Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.62 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5154432 | 0.90 | MCHR1 (0.59) | MCHR1CHRM1HTR2ACYP2D6CYP1A2 | |
| SCHEMBL5155133 | 0.86 | MCHR1 (0.59) | MCHR1CHRM1HTR2ACYP2D6CYP1A2 | |
| SCHEMBL2319440 | 0.82 | MCHR1 (0.68) | MCHR1CHRM1HTR2ACYP2D6CYP1A2 | |
| SCHEMBL4493271 | 0.81 | MCHR1 (0.63) | MCHR1CHRM1HTR2ACYP2D6LMNA | |
| SCHEMBL4491965 | 0.81 | MCHR1 (0.63) | MCHR1CHRM1HTR2ACYP2D6CYP1A2 | |
| SCHEMBL4489001 | 0.81 | MCHR1 (0.63) | MCHR1CHRM1HTR2ACYP2D6LMNA | |
| SCHEMBL5199712 | 0.81 | MCHR1 (0.64) | MCHR1CHRM1HTR2ACYP2D6CYP1A2 | |
| SCHEMBL4471247 | 0.80 | MCHR1 (0.62) | MCHR1CHRM1HTR2ACYP2D6CYP1A2 | |
| SCHEMBL5230359 | 0.80 | MCHR1 (0.63) | MCHR1CHRM1HTR2ACYP2D6CYP1A2 | |
| SCHEMBL4493267 | 0.80 | MCHR1 (0.61) | MCHR1CHRM1HTR2ACYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737823-A2 | NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS COMPRISING SAID COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005103002-A2 | NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS COMPRISING SAID COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-03 | — | — | WO | disclosed |